Dynamic cellular microenvironments
The extracellular matrix (ECM) is the natural material niche of the human body. By coordinating a complex array of biochemical and biophysical cues, the ECM plays an important role in both normal physiological processes, such as growth and development, and pathophysiological processes, such as disease. However, nearly all commercially available cell culture platforms or scaffolds are static, which can lead to a mismatch between in vitro experiments and in vivo behavior. To further our understanding of in vivo processes, we are developing new materials that can mimic the dynamic properties of real tissues. Our current focus is to engineer well-defined polymeric hydrogels with precise temporal control over bulk and local mechanics using stimuli-responsive chemistries. Broadly, we apply our materials toward understanding disease mechanisms (especially fibrosis), as well as advanced tissue engineering scaffolds, cell expansion and delivery vehicles, and diagnostic screening platforms.
A.M. Rosales, S.L. Vega, F.W. DelRio, J.A. Burdick, K.S. Anseth. “Hydrogels with Reversible Mechanics to Probe Dynamic Cell Microenvironments.” Angewandte Chemie, in press.
E.M. Nehls, A.M. Rosales, K.S. Anseth. “Enhanced User-control of Small Molecule Drug Release from a Poly(ethylene glycol) Hydrogel via Azobenzene/Cyclodextrin Complex Tether.” Journal of Materials Chemistry B, 2016, 4, 1035-1039.
A.M. Rosales and K.S. Anseth. “The Design of Reversible Hydrogels to Capture Extracellular Matrix Dynamics.” Nature Reviews Materials, 2016, 1, 15012.
A.M. Rosales, K.M. Mabry, E.M. Nehls, K.S. Anseth. “Photoresponsive Elastic Properties of
Azobenzene-Containing Poly(ethylene-glycol)-based Hydrogels.” Biomacromolecules 2015, 16(3), 798-806.