sequence defined materials
Biological polymers such as proteins are responsible for nearly every facet of life and contain exquisite properties ranging from structural (e.g., spider silk) to signal transduction (e.g., insulin). Both monomer sequence and chain shape dictate protein function, but such sequence control is difficult to replicate with conventional synthetic polymers. Our work probes the relationship between sequence and structure using a simplified class of biomimetic materials, polypeptoids, and we leverage this molecular control to develop synthetic materials with enhanced bioactivity. Because polypeptoids are non-natural, they provide opportunities to interface with biologics in an orthogonal manner and to generate self-assembled materials with precise control.
A.M. Rosales, R.A. Segalman, R.N. Zuckermann. “Polypeptoids: A Model System to Study the Effect of Monomer Sequence on Polymer Properties and Self-Assembly.” Soft Matter 2013, 9, 8400-8414.
A.M. Rosales, B.L. McCulloch, R.N. Zuckermann, R.A. Segalman. “Tunable Phase Behavior of Polystyrene-Polypeptoid Block Copolymers” Macromolecules 2012, 45(15),6027-6035
A.M. Rosales, H.K. Murnen, S.R. Kline, R.N. Zuckermann, R.A. Segalman. “Determination of the Persistence Length of Helical and Non-Helical Polypeptoids in Solution.” Soft Matter 2012, 8, 3673-3680.